FD-OCT and IVUS for detection of incomplete stent apposition in heavily calcified vessels: novel insights.

Correspondence to Dr Georg M Fröhlich; [email protected] In the present issue of Open Heart, Gudmundsdottir and colleagues compare two intracoronary imaging modalities, intravascular ultrasound (IVUS) and FD-optical coherence tomography (FD-OCT), in patients undergoing complex percutaneous coronary intervention (PCI) with rotablation for calcific coronary lesions. In particular, this study sought to detect incomplete stent apposition (ISA) using these different imaging modalities. ISA may play a role in the risk of target vessel failure, for example, stent thrombosis. Intracoronary imaging has become widely available with the advent of IVUS in the early 1990s. IVUS-derived images with an axial resolution down to 150 μm have given novel insights into the clinical evolution of coronary artery disease and plaque composition. This technology was rapidly embraced by the interventional cardiology community, mainly to assess coronary lesions of intermediate significance in larger coronary arteries, to size the stent diameter or to monitor optimal stent deployment and exclude coronary dissections post-stenting. While this new intracoronary imaging fuelled enthusiasm, to date, limited data exist to demonstrate that IVUS-guided PCI translates into a superior clinical outcome with respect to incomplete stent apposition (table 1). However, a large observational analysis comparing IVUS-guided against angiography-guided PCI suggested that IVUS guidance was associated with a reduction in stent thrombosis, myocardial infarction and major adverse cardiac events within 1 year after DES implantation. Moreover, some moderately sized clinical studies suggested an improved performance if IVUS was used, particularly for complex PCI procedures involving the left main stem. There are several limitations inherent in this technology. First, the spatial resolution may be limited for optimal stent evaluation. Second, heavy calcification may cause artefacts and compromise image quality. And third, IVUS further increases procedural costs. Current European Society of Cardiology guidelines suggest a class IIa recommendation for the use of IVUS to optimise stent implantation in selected patients, to assess severity of left main stem disease and optimise left main stenting, and to reveal mechanisms of stent failure (eg, stent thrombosis). The first coronary FD-OCT images in humans were published in 2002. A major advantage of this technology is indeed the higher resolution, so that FD-OCT allows for qualitative plaque assessment with respect to plaque cap thickness or rupture. However, definitions on plaque vulnerability by FD-OCT are still under development. FD-OCT was also referred to as ‘virtual histology’ due to its excellent axial resolution down to 15 μm. This level of accuracy owes to emission of light of a near infrared spectrum (approximately 1300 nm) and immediate acquisition of backscattering by the FD-OCT probe. Optimal image acquisition may only be achieved if red blood cells are cleared sufficiently from the vessel lumen during a flush with transparent contrast die. Given the low penetration depth (1.0– 1.5 mm) of near infrared light, only the inner vessel layers may be visualised with FD-OCT, while the whole vessel plaque burden can only be estimated with IVUS. On the other hand, heavy vessel calcification does not necessarily impact on image quality in FD-OCT. In summary, the ESC guidelines do recommend FD-OCT to assess mechanisms of stent failure (class IIa) and to optimise stent implantation in selected patients (class IIb). Gudmundsdottir and colleagues investigated both intracoronary imaging modalities in a subset of patients with heavily calcified coronary lesions who underwent rotablation and PCI. The primary outcome measure in this study was the detection of ISA to the